Spravato vs Ketamine: What’s the Difference?
If you’re researching new treatment options for depression, you’ve probably seen both Spravato® and ketamine therapy mentioned. Many patients are unsure how these treatments differ and which option might be right for them.
Our clinic is located in Southlake and serves patients across the Dallas–Fort Worth area. Below is a clear, simple explanation of the differences between Spravato and ketamine therapy.
What is Spravato?
Spravato® is an FDA-approved nasal spray medication derived from ketamine. The active ingredient is esketamine, which is a form of ketamine developed specifically for treating depression.
Spravato is typically prescribed for:
- Treatment-resistant depression
- Depression with suicidal thoughts
Unlike traditional antidepressants, Spravato works on the brain’s glutamate system rather than serotonin or dopamine.
Many insurance plans cover Spravato treatment in Dallas when patients meet medical criteria.
What is ketamine therapy?
Ketamine has been used safely in medicine for decades. In mental health treatment, it is used in carefully controlled doses to help improve mood and reduce symptoms of depression and anxiety.
Ketamine therapy may be recommended for:
- Depression
- Anxiety disorders
- PTSD
- OCD
- Mood disorders
Clinics may offer ketamine therapy in Dallas using in-office treatment sessions supervised by medical professionals.
Key differences between Spravato and ketamine
FDA approval
Spravato is FDA-approved specifically for depression. Ketamine is commonly used off-label for mental health treatment.
Insurance coverage
Spravato is often covered by insurance. Ketamine therapy is typically self-pay.
Administration
Spravato is a nasal spray. Ketamine treatment may be delivered through in-office sessions depending on the clinic.
Treatment planning
Both treatments involve medical screening, monitoring, and follow-up care.
Which treatment is better?
There is no one-size-fits-all answer. The best treatment depends on medical history, insurance coverage, treatment goals, and response to previous medications.
A consultation with a clinician can help determine whether Spravato or ketamine may be appropriate.
Next steps
If you’re exploring new treatment options, the first step is meeting with a clinician to discuss your history and goals.
You can learn more about both Spravato treatment and ketamine therapy and schedule a consultation online.